| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2021-10-26 |
| タイトル |
|
|
タイトル |
Impact of CYP2D6 Activity and Cachexia Progression on Enantiomeric Alteration of Plasma Tramadol and Its Demethylated Metabolites and Their Relationships with Central Nervous System Symptoms in Head and Neck Cancer Patients |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
tramadol |
| キーワード |
|
|
主題 |
enantiomers |
| キーワード |
|
|
主題 |
metabolite |
| キーワード |
|
|
主題 |
CYP2D6 |
| キーワード |
|
|
主題 |
cancer cachexia |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| その他のタイトル |
|
|
その他のタイトル |
Impact of CYP2D6 and Cachexia on Tramadol Kinetics |
| 著者 |
Suzuki, Koji
Naito, Takafumi
Tanaka, Hironari
Shibata, Kaito
Yamada, Yasuhide
Itoh, Kunihiko
Kawakami, Junichi
|
| 書誌情報 |
Basic & Clinical Pharmacology & Toxicology
巻 128,
号 3,
p. 472-481,
発行日 2021-03
|
| 出版者 |
|
|
出版者 |
John Wiley and Sons |
| 権利 |
|
|
権利情報 |
"This is the peer reviewed version of the following article: ""Impact of CYP2D6 Activity and Cachexia Progression on Enantiomeric Alteration of Plasma Tramadol and Its Demethylated Metabolites and Their Relationships with Central Nervous System Symptoms in Head and Neck Cancer Patients"", Basic & Clinical Pharmacology & Toxicology; 128(3): p472-481, 2021, which has been published in final form at https://doi.org/10.1111/bcpt.13528. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited." |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
This study aimed to evaluate the influence of CYP2D6 activity and cachexia progression on the enantiomeric alteration of plasma tramadol and its demethylated metabolites in head and neck cancer patients. Fifty-three head and neck cancer patients receiving oral tramadol were enrolled. The plasma concentrations of tramadol, O-desmethyltramadol (ODT), and N-desmethyltramadol (NDT) enantiomers were determined. The CYP2D6 activity score (AS) and degree of cachexia progression were assessed according to genotype and the Glasgow Prognostic Score (GPS), respectively. The enantiomeric ratio of NDT was (+)-form dominant in all patients. CYP2D6 AS had negative correlations with the plasma concentrations of (+)-NDT and (?)-NDT. The plasma concentrations of (+)-tramadol and (+)-ODT were higher in patients with GPS 1 or 2 than in those with GPS 0. Lower metabolic ratios to NDT enantiomers were observed in patients with GPS 1 or 2. In patients with GPS 1 or 2, the plasma (?)-tramadol was associated with the incidence of central nervous system symptoms. In conclusion, CYP2D6 AS partially explained the contribution of CYP2D6 activity to plasma tramadol and its demethylated metabolite enantiomers. Additionally, cachexia progression elevated the plasma (+)-tramadol and (+)-ODT levels through the reduction of N-demethylation of (+)-tramadol. |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1742-7835 |
| EISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1742-7843 |
| PubMed番号 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
33131142 |
| 出版社DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1111/bcpt.13528 |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
BCPT-128-472.pdf (1.3 MB)
