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Early changes of pulmonary arterial hemodynamics in patients with systemic sclerosis: Flow pattern, WSS and OSI analysis with 4D Flow MRI
http://hdl.handle.net/10271/00003917
http://hdl.handle.net/10271/00003917ae30598b-56ed-4454-ace4-bae3c1141728
| 名前 / ファイル | ライセンス | アクション |
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ER-31-4253.pdf (2.0 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||
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| 公開日 | 2021-11-01 | |||||||||||||||||||||
| タイトル | ||||||||||||||||||||||
| タイトル | Early changes of pulmonary arterial hemodynamics in patients with systemic sclerosis: Flow pattern, WSS and OSI analysis with 4D Flow MRI | |||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| 言語 | ||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題 | Magnetic resonance imaging | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題 | pulmonary artery | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題 | hemodynamics | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題 | blood flow velocity | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題 | systemic sclerosis | |||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||
| 著者 |
Ikoma, Takenori
× Ikoma, Takenori
× Suwa, Kenichiro
× Sano, Makoto
× Ushio, Takasuke
× Saotome, Masao
× Ogawa, Noriyoshi
× Satoh, Hiroshi
× Maekawa, Yuichiro
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| 書誌情報 |
European Radiology 巻 31, 号 6, p. 4253-4263, 発行日 2021-06 |
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| 出版者 | Springer Nature | |||||||||||||||||||||
| 権利 | ||||||||||||||||||||||
| 権利情報 | "This is a post-peer-review, pre-copyedit version of an article published in ""European Radiology"". The final authenticated version is available online at: http://dx.doi.org/10.1007/s00330-020-07301-x." | |||||||||||||||||||||
| 抄録 | ||||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||||
| 内容記述 | Objectives- To study the pulmonary artery (PA) hemodynamics in patients with systemic sclerosis (SSc) using 4D flow MRI (4D-Flow). Methods - Twenty-three patients with SSc (M/F: 2/21, 57±15 years, 3 manifest PA hypertension (PAH) by right heart catheterization) and 10 control subjects (M/F: 1/9, 55±17 years) underwent 4D-Flow for the in vivo measurement of 3D blood flow velocities in the PA. Data analysis included area-averaged flow quantification at the main PA, 3D wall shear stress (WSS), oscillatory shear index (OSI) calculation along the PA surface and Reynolds number. The composite outcome of all-cause death and major adverse cardiac events was also investigated. Results- The maximum PA flow at the systole didn’t differ, but the minimum flow at the diastole was significantly greater in patients with SSc compared to that in control subjects (7.7±16.0 ml/s vs. -13.0±17.3 ml/s, p<0.01). The maximum WSS at the peak systole was significantly lower and OSI was significantly greater in patients with SSc compared to those in control subjects (maximum WSS: 1.04±0.20 Pa vs. 1.33±0.34 Pa, p<0.01, OSI: 0.139±0.031 vs. 0.101±0.037, p<0.01). The cumulative event-free rate for the composite event were significantly lower in patients with minimum flow in main PA?9.22 ml/s (p=0.012) and in patients with Reynolds number?2560 (p<0.001). Conclusions- 4D-Flow has the potential to detect changes of PA hemodynamics noninvasively and predict the outcome in patients with SSc at the stage before manifest PAH. |
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| 抄録 | ||||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||||
| 内容記述 | Key points ・The WSS at the peak systolic phase was significantly lower (p<0.05), whereas OSI were greater (p<0.01) in patients with SSc without manifest PAH than controls. ・The hemodynamic change detected by 4D-Flow may help patient management even at the stage before manifest PAH in SSc. ・The minimum PA flow and Reynolds number by 4D-Flow will serve as a predictive marker for SSc. |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||
| 収録物識別子 | 0938-7994 | |||||||||||||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||
| 収録物識別子 | 1432-1084 | |||||||||||||||||||||
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| 関連タイプ | isVersionOf | |||||||||||||||||||||
| 識別子タイプ | PMID | |||||||||||||||||||||
| 関連識別子 | 33211148 | |||||||||||||||||||||
| 出版社DOI | ||||||||||||||||||||||
| 関連タイプ | isVersionOf | |||||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||||
| 関連識別子 | 10.1007/s00330-020-07301-x | |||||||||||||||||||||
| 著者版フラグ | ||||||||||||||||||||||
| 出版タイプ | AM | |||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||||||
