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Effect of hyperbarically oxygenated-perfluorochemical with University of Wisconsin solution on preservation of rat small intestine using an original pressure-resistant portable apparatus
http://hdl.handle.net/10271/56
http://hdl.handle.net/10271/56be0b42e9-60e2-4ff9-900f-1a574454f425
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
論文本文 (539.9 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||
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| 公開日 | 2013-08-27 | |||||||
| タイトル | ||||||||
| タイトル | Effect of hyperbarically oxygenated-perfluorochemical with University of Wisconsin solution on preservation of rat small intestine using an original pressure-resistant portable apparatus | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 主題 | small intestine | |||||||
| キーワード | ||||||||
| 主題 | perfluorochemical | |||||||
| キーワード | ||||||||
| 主題 | hyperbaric oxygen | |||||||
| キーワード | ||||||||
| 主題 | transplantation | |||||||
| キーワード | ||||||||
| 主題 | UW solution | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||
| 資源タイプ | doctoral thesis | |||||||
| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| その他のタイトル | ||||||||
| その他のタイトル | 携帯型耐圧保存装置を用いたラット切除小腸の保存に対する高圧酸素化パーフルオロケミカルとウィスコンシン液の効果 | |||||||
| 著者 |
Inuzuka, Kazunori
× Inuzuka, Kazunori
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| 書誌情報 |
en : Surgery 巻 142, 号 1, p. 57-66, 発行日 2007-07-11 |
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| 出版者 | ||||||||
| 出版者 | Elsevier | |||||||
| 言語 | en | |||||||
| 権利 | ||||||||
| 言語 | en | |||||||
| 権利情報 | Copyright 2007 Mosby, Inc. All rights reserved | |||||||
| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Background. Perfluorochemicals (PFC) are chemical substances that have a higher oxygen solubility under hyperbaric oxygen (HBO) pressure. This study investigated the effect of cold HBO-PFC/UW solution on preservation of rat small intestinal graft. Methods. We manufactured an air-tight, pressure resistant tank which was made of stainless steel with high thermal conductivity. Rat ileal grafts were placed in a custom-made silicon-gum bag with UW solution, which was immersed in 5 atm HBO-PFC solution in the tank (Group P-5). The tank was placed at 4℃. We compared the ATP concentration and mucosal permeability in Group P-5 with grafts preserved in 1 atm oxygenated-PFC/UW solution (Group P-1) and simple cold storage in UW solution (Group C). Histological study was also performed. Results. PO2 in UW solution after 48 hours preservation were 1851.6 ± 36.9, 498.5 ± 12.5, and 173.3 ± 3.4 mmHg (Group P-5, P-1 and C, respectively, mean ± SD). At that time, graft ATP concentration was significantly higher in Group P-5 compare to that in Group P-1 and Group C. Mucosal hyperpermeability as well as mucosal morphological changes were also ameliorated in the Group P-5. Conclusion. HBO-PFC could supply a larger amount of oxygen to UW solution. Indirect measures of oxygen metabolism such as ATP content and lactate production suggested improvement in maintaining graft oxygen metabolism. |
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| 言語 | en | |||||||
| 注記 | ||||||||
| 内容記述 | 浜松医科大学学位論文 医博第499号(平成20年3月17日） | |||||||
| 学位名 | ||||||||
| 学位名 | 博士（医学） | |||||||
| 学位の区分 | ||||||||
| 内容記述 | doctoral | |||||||
| 学位の分野 | ||||||||
| 内容記述 | 医学系研究科 | |||||||
| 学位授与機関 | ||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||
| 学位授与機関識別子 | 13802 | |||||||
| 学位授与機関名 | 浜松医科大学 | |||||||
| 学位授与年月日 | ||||||||
| 学位授与年月日 | 2008-03-17 | |||||||
| 学位授与番号 | ||||||||
| 学位授与番号 | 甲第499号 | |||||||
| ISSN | ||||||||
| 収録物識別子タイプ | PISSN | |||||||
| 収録物識別子 | 0039-6060 | |||||||
| EISSN | ||||||||
| 収録物識別子タイプ | EISSN | |||||||
| 収録物識別子 | 1532-7361 | |||||||
| PubMed番号 | ||||||||
| 識別子タイプ | PMID | |||||||
| 関連識別子 | 17630001 | |||||||
| 出版社DOI | ||||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | https://doi.org/10.1016/j.surg.2007.03.002 | |||||||
| 関連サイト | ||||||||
| 識別子タイプ | HDL | |||||||
| 関連識別子 | http://hdl.handle.net/10271/55 | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | AM | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||
