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Mechanical weakness of thoracic aorta related to aging or dissection predicted by speed-of-sound with collagenase
http://hdl.handle.net/10271/00003939
http://hdl.handle.net/10271/0000393976a73cd2-33eb-4569-9bf6-79c0333b2335
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Ultrasound Med Biol-45-3102.pdf (2.1 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
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| 公開日 | 2022-01-26 | |||||||||
| タイトル | ||||||||||
| タイトル | Mechanical weakness of thoracic aorta related to aging or dissection predicted by speed-of-sound with collagenase | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| キーワード | ||||||||||
| 主題 | scanning acoustic microscopy | |||||||||
| キーワード | ||||||||||
| 主題 | collagenase | |||||||||
| キーワード | ||||||||||
| 主題 | extracellular matrix | |||||||||
| キーワード | ||||||||||
| 主題 | thoracic aorta | |||||||||
| キーワード | ||||||||||
| 主題 | medial degeneration grade | |||||||||
| キーワード | ||||||||||
| 主題 | aging | |||||||||
| キーワード | ||||||||||
| 主題 | dissected aorta | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| 著者 |
Miura, Katsutoshi
× Miura, Katsutoshi
× Yamashita, Kanna
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| 書誌情報 |
Ultrasound in Medicine & Biology 巻 45, 号 12, p. 3102-3115, 発行日 2019-12 |
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| 出版者 | ||||||||||
| 出版者 | Elsevier | |||||||||
| 権利 | ||||||||||
| 権利情報 | © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||||||
| 権利 | ||||||||||
| 権利情報 | This is the accepted manuscript version. The formal published version is available at "https://doi.org/10.1016/j.ultrasmedbio.2019.08.012". | |||||||||
| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Scanning acoustic microscopy reveals information about histology and speed-of-sound (SOS) through tissues. Slower SOS corresponds to lower stiffness. The present study aimed to investigate whether SOS values reflect the degree of degeneration with aging or dissection and whether enzymatic digestion susceptibility is distinct. SOS of media besides the atheromatous areas of normal and surgical dissections was measured and compared using medial degeneration grade (MDG) scores. To evaluate the damage rate, SOS was assessed following collagenase digestion. SOS scores negatively correlated with aging and MDG scores. Dissected aortae showed higher SOS and MDG scores without age correlation. Collagenase digestion was present in all aortae, but older aortae were more injured than younger aortae. Dissected aortae were more vulnerable to collagenase. Older and dissected aortae expressed specific extracellular matrix (ECM) components to compensate for mechanical weakness. The present method can evaluate mechanical weakness corresponding to histology to investigate the cause of rupture. | |||||||||
| ISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 0301-5629 | |||||||||
| EISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 1879-291X | |||||||||
| PubMed番号 | ||||||||||
| 関連タイプ | isVersionOf | |||||||||
| 識別子タイプ | PMID | |||||||||
| 関連識別子 | 31537389 | |||||||||
| 出版社DOI | ||||||||||
| 関連タイプ | isVersionOf | |||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | 10.1016/j.ultrasmedbio.2019.08.012 | |||||||||
| 著者版フラグ | ||||||||||
| 出版タイプ | AM | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||
