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Mass spectrometry-based phospholipid imaging: methods and findings
http://hdl.handle.net/10271/00003947
http://hdl.handle.net/10271/0000394736bc6488-5381-4a74-9b9d-0ac897b8f740
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Expert Rev Proteomics-17-843.pdf (967.0 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||
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| 公開日 | 2022-02-08 | |||||||||||||||||
| タイトル | ||||||||||||||||||
| タイトル | Mass spectrometry-based phospholipid imaging: methods and findings | |||||||||||||||||
| 言語 | ||||||||||||||||||
| 言語 | eng | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | Phospholipid | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | Mass spectrometry imaging | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | MALDI-MSI | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | DESI-MSI | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | SIMS imaging | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||
| 著者 |
Mamun, Md. Al
× Mamun, Md. Al
× Islam, Ariful
× Eto, Fumihiro
× Sato, Tomohito
× Kahyo, Tomoaki
× Setou, Mitsutoshi
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| 書誌情報 |
Expert Review of Proteomics 巻 17, 号 11-12, p. 843-854, 発行日 2020-12 |
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| 出版者 | ||||||||||||||||||
| 出版者 | Taylor & Francis | |||||||||||||||||
| 権利 | ||||||||||||||||||
| 権利情報 | This is an Accepted Manuscript of an article published by Taylor & Francis in "Expert Review of Proteomics" on 28/01/2021, available online: http://www.tandfonline.com/10.1080/14789450.2020.1880897. | |||||||||||||||||
| 抄録 | ||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||
| 内容記述 | Introduction: Imaging is a technique used for direct visualization of the internal structure or distribution of biomolecules of a living system in a two-dimensional or three-dimensional fashion. Phospholipids are important structural components of biological membranes and have been reported to be associated with various human diseases. Therefore, the visualization of phospholipids is crucial to understand the underlying mechanism of cellular and molecular processes in normal and diseased conditions. Areas covered: Mass spectrometry imaging (MSI) has enabled the label-free imaging of individual phospholipids in biological tissues and cells. The commonly used MSI techniques include matrix-assisted laser desorption ionization-MSI (MALDI-MSI), desorption electrospray ionization-MSI (DESI-MSI), and secondary ion mass spectrometry (SIMS) imaging. This special report described those methods, summarized the findings, and discussed the future development for the imaging of phospholipids. Expert opinion: Phospholipids imaging in complex biological samples has been significantly benefited from the development of MSI methods. In MALDI-MSI, novel matrix that produces homogenous crystals exclusively with polar lipids is important for phospholipids imaging with greater efficiency and higher spatial resolution. DESI-MSI has the potential of live imaging of the biological surface while SIMS is expected to image at the subcellular level in the near future. |
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| 抄録 | ||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||
| 内容記述 | Highlights: 1. Mass spectrometry imaging (MSI) is a powerful method for imaging specific phospholipids (PLs) in tissues and cells. 2. The potential of MSI of either single or multiple PLs for the development of therapeutic agents, biomarkers, and predictive factors for diseases is reviewed. 3. The current states of MALDI-MSI, DESI-MSI, and SIMS-MSI on tissue PL imaging are assessed and discussed. 4. By image reconstruction, conventional 2D imaging can be applied in 3D PL imaging. |
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| ISSN | ||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||
| 収録物識別子 | 1478-9450 | |||||||||||||||||
| EISSN | ||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||
| 収録物識別子 | 1744-8387 | |||||||||||||||||
| PubMed番号 | ||||||||||||||||||
| 関連タイプ | isVersionOf | |||||||||||||||||
| 識別子タイプ | PMID | |||||||||||||||||
| 関連識別子 | 33504247 | |||||||||||||||||
| 出版社DOI | ||||||||||||||||||
| 関連タイプ | isVersionOf | |||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||
| 関連識別子 | 10.1080/14789450.2020.1880897 | |||||||||||||||||
| 著者版フラグ | ||||||||||||||||||
| 出版タイプ | AM | |||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||
