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Histological evaluation of thyroid lesions using a scanning acoustic microscope
http://hdl.handle.net/10271/00004078
http://hdl.handle.net/10271/000040788fb2336b-bf97-43d2-8daf-3d83aa24a7a6
| 名前 / ファイル | ライセンス | アクション |
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PLMI-6-1.pdf (7.7 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
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| 公開日 | 2022-03-15 | |||||||||
| タイトル | ||||||||||
| タイトル | Histological evaluation of thyroid lesions using a scanning acoustic microscope | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| キーワード | ||||||||||
| 主題 | scanning acoustic microscope | |||||||||
| キーワード | ||||||||||
| 主題 | tissue elasticity | |||||||||
| キーワード | ||||||||||
| 主題 | cancer imaging | |||||||||
| キーワード | ||||||||||
| 主題 | thyroid tumor | |||||||||
| キーワード | ||||||||||
| 主題 | parathyroid | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| 著者 |
Miura, Katsutoshi
× Miura, Katsutoshi
× Mineta, Hiroyuki
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| 書誌情報 |
Pathology and Laboratory Medicine International 巻 6, p. 1-9, 発行日 2014-02-11 |
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| 出版者 | ||||||||||
| 出版者 | Dovepress | |||||||||
| 権利 | ||||||||||
| 権利情報 | © 2014 Miura and Mineta. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php | |||||||||
| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Purpose: A scanning acoustic microscope (SAM) uses an ultrasound to image an object by plotting the speed-of-sound (SOS) through tissues on screen. Because hard tissues result in great SOS, SAM can provide data on the tissue elasticity. This paper investigated the utility of SAM in evaluating thyroid lesions. Methods: Formalin-fixed, paraffin sections were scanned with a 120 MHz transducer. SOS through each area was calculated and plotted on the screen to provide histological images, and SOS of each lesion was compared and statistically analyzed. Results: High-concentrated colloids, red blood cells, and collagen fibers showed great SOS, while low-concentrated colloids, parathyroids, lymph follicles, and epithelial tissues including carcinomas demonstrated lower SOS. SAM clearly discriminated structure of thyroid components corresponding to low magnification of light microscopy. Thyroid tumors were classified into three groups by average SOS: the fast group consisted of follicular adenomas/carcinomas and malignant lymphomas; the slow group contained poorly differentiated/undifferentiated carcinomas; and the intermediate group comprised papillary/medullary carcinomas. Fragmented colloids, irregular-shaped follicles, and desmoplastic reactions were observed in the invasive area of surrounding carcinomas. Conclusion: The SAM imaging method had the following benefits: 1) precise images were acquired in a few minutes without special staining; 2) structural irregularity and desmoplastic reactions, which indicated malignancy, were detected; 3) images reflected tissue elasticity, which was statistically comparable among lesions by SOS; 4) follicular functional activity was predictable by converting colloid concentration to SOS; and 5) tumor classification was predictable by SOS because more poorly differentiated carcinomas had a tendency to show lower SOS. |
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| ISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 1179-2698 | |||||||||
| 出版社DOI | ||||||||||
| 関連タイプ | isIdenticalTo | |||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | 10.2147/PLMI.S58343 | |||||||||
| 著者版フラグ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
