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  1. 学術雑誌論文
  2. 各雑誌掲載論文

Microscopic observation of chemical modification in sections using scanning acoustic microscopy

http://hdl.handle.net/10271/00004080
http://hdl.handle.net/10271/00004080
743d0f86-06f9-4805-9139-b76e43481020
名前 / ファイル ライセンス アクション
Pathol Pathol Int-65-355.pdf (2.4 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2022-03-15
タイトル
タイトル Microscopic observation of chemical modification in sections using scanning acoustic microscopy
言語
言語 eng
キーワード
主題 ageing
キーワード
主題 elasticity
キーワード
主題 formalin fixation
キーワード
主題 histochemistry
キーワード
主題 histopathology
キーワード
主題 imaging analysis
キーワード
主題 pepsin
キーワード
主題 periodic acid-Schiff reaction
キーワード
主題 ultrasound
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
その他のタイトル
その他のタイトル Ultrasound detection of tissue modification
著者 Miura, Katsutoshi

× Miura, Katsutoshi

Miura, Katsutoshi

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Egawa, Yuki

× Egawa, Yuki

Egawa, Yuki

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Moriki, Toshiaki

× Moriki, Toshiaki

Moriki, Toshiaki

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Mineta, Hiroyuki

× Mineta, Hiroyuki

Mineta, Hiroyuki

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Harada, Hidekazu

× Harada, Hidekazu

Harada, Hidekazu

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Baba, Satoshi

× Baba, Satoshi

Baba, Satoshi

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Yamamoto, Seiji

× Yamamoto, Seiji

Yamamoto, Seiji

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書誌情報 Pathology International

巻 65, 号 7, p. 355-366, 発行日 2015-07
出版者
出版者 John Wiley and Sons
権利
権利情報 This is the peer reviewed version of the following article: "Microscopic observation of chemical modification in sections using scanning acoustic microscopy", Pathology International; 65(7): p355-366, 2015, which has been published in final form at https://doi.org/10.1111/pin.12288. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
抄録
内容記述タイプ Abstract
内容記述 A scanning acoustic microscope (SAM) calculates the speed of sound (SOS) through tissues and plots the data on the screen to form images. Hard tissues result in greater SOS; based on these differences in tissue properties regarding SOS, SAM can provide data on tissue elasticity. The present study evaluated whether tissue modifications, such as formalin fixation, periodic acid-Schiff (PAS) reactions and protein degradation, changed the acoustic properties of the tissues and whether SAM could be a useful tool for following chemical changes in sections. The fixation process was observable by the increased SOS. During the PAS reaction, the glycosylation of tissues was characterized by an increased SOS. Mucous or glycogen distribution was visualised and was found to be statistically comparable among lesions and states. Protease digestion by pepsin led to a decreased SOS. Tissue sensitivity to proteases varied due to the stage, cause and duration of inflammation or ageing. Changes in acoustic properties were more sensitive than those in optical histology. SAM facilitates the visualisation of the time course or distribution of chemical modifications in tissue sections, thus aiding their comparison among tissues. SAM may be an effective tool for studying changes such as protein cross-linkage, tissue repair and ageing.
ISSN
収録物識別子タイプ ISSN
収録物識別子 1320-5463
EISSN
収録物識別子タイプ ISSN
収録物識別子 1440-1827
PubMed番号
関連タイプ isVersionOf
識別子タイプ PMID
関連識別子 25824722
医中誌論文ID
関連タイプ isVersionOf
識別子タイプ ICHUSHI
関連識別子 2016231362
出版社DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 10.1111/pin.12288
著者版フラグ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
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