| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2022-04-08 |
| タイトル |
|
|
タイトル |
HPV関連中咽頭癌例に対する血液循環腫瘍DNAを用いたリキッドバイオプシーの有用性 |
| タイトル |
|
|
タイトル |
Value of Liquid Biopsy Monitoring of Circulating Tumor DNA in HPV-Associated Oropharyngeal Cancer |
|
言語 |
en |
| 言語 |
|
|
言語 |
jpn |
| キーワード |
|
|
主題 |
liquid biopsy |
| キーワード |
|
|
主題 |
circulating tumor DNA |
| キーワード |
|
|
主題 |
HPV-associated oropharyngeal cancer |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
今井, 篤志
三澤, 清
山田, 智史
岡村, 純
望月, 大極
山口, 裕貴
瀧澤, 義徳
細川, 誠二
峯田, 周幸
|
| 書誌情報 |
耳鼻咽喉科臨床 補冊 = Practica oto-rhino-laryngologica. Suppl.
巻 156,
p. 1-7,
発行日 2021-02-01
|
| 出版者 |
|
|
出版者 |
耳鼻咽喉科臨床学会 |
| 出版者 |
|
|
出版者 |
The Society of Practical Otolaryngology |
| 権利 |
|
|
権利情報 |
出版者の許諾を得て掲載 |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Liquid biopsy has the alternative utility, besides being a diagnostic tool, as a minimally invasive monitoring tool for disease profiling and prognostication. Recently, the incidence of HPV-associated oropharyngeal cancer has been increasing. Also, the choices of chemotherapy, including immune checkpoint inhibitor therapy, has been increasing. A minimally invasive diagnostic tool is desired.
Herein, we demonstrate the usefulness of liquid biopsy, not only for HPV ctDNA monitoring, but also for diagnosis of recurrence, in a patient with HPV-OPC. The ctDNA concentrations decreased and serum HPV-DNA became negative after surgery for the primary tumor. When the patient developed a pulmonary lesion during the follow-up after initial treatment, we initially suspected primary lung cancer clinically. The operated lesion turned out to be a metastatic lesion. The test for HPV-DNA, which had become negative before, had become positive before the pulmonary surgery, suggesting recurrent disease.
Liquid biopsy for monitoring of the ctDNA has the potential to allow the disease status to be monitored in patients with HPV-OPC. |
| 注記 |
|
|
内容記述 |
浜松医科大学医学部耳鼻咽喉科・頭頸部外科学教室 峯田周幸教授退任記念論文集～症例から学ぶ～ |
| 注記 |
|
|
内容記述 |
Festschrift for Professor Hiroyuki Mineta In Hornor of His Retirement as Chairman of Hamamatsu University School of Medicine |
| ISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0912-1870 |
| EISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
2185-1557 |
| 医中誌論文ID |
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|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
ICHUSHI |
|
|
関連識別子 |
2021267582 |
| 出版社DOI |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.5631/jibirinsuppl.156.1 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
耳鼻臨床補冊-156-1.pdf (1.0 MB)
