| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2022-06-10 |
| タイトル |
|
|
タイトル |
Evaluation of definitive chemoradiotherapy versus radical esophagectomy in clinical T1bN0M0 esophageal squamous cell carcinoma |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
esophageal squamous cell carcinoma |
| キーワード |
|
|
主題 |
esophagectomy |
| キーワード |
|
|
主題 |
chemoradiotherapy |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| その他のタイトル |
|
|
その他のタイトル |
Chemoradiotherapy versus esophagectomy for early esophageal cancer |
| 著者 |
Haneda, Ryoma
Booka, Eisuke
Ishii, Kenjiro
Kikuchi, Hirotoshi
Hiramatsu, Yoshihiro
Kamiya, Kinji
Ogawa, Hirofumi
Yasui, Hirofumi
Takeuchi, Hiroya
Tsubosa, Yasuhiro
|
| 書誌情報 |
World Journal of Surgery
巻 45,
号 6,
p. 1835-1844,
発行日 2021-06
|
| 出版者 |
|
|
出版者 |
Springer Nature |
| 権利 |
|
|
権利情報 |
This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00268-021-06016-4 |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background: The standard treatment for patients with clinical T1bN0M0 esophageal squamous cell carcinoma is radical esophagectomy. Definitive chemoradiotherapy is regarded as a treatment option, and recently, good clinical outcomes of this treatment have been reported. This study compared prognosis after definitive chemoradiotherapy with radical esophagectomy.
Methods: From January 2011 to December 2019, 68 consecutive patients who were diagnosed clinical T1bN0M0 squamous cell carcinoma were enrolled and investigated retrospectively. Patients were classified into two groups whether treated by surgery or definitive chemoradiotherapy. Survival outcomes were compared and subsequent therapies after recurrence were also investigated.
Results: Among 68 patients, 39 patients underwent surgery and 29 patients received definitive chemoradiotherapy. No significant difference was noted in overall survival between the two groups. However, the rate of 5-year recurrence free survival was significantly lower in definitive chemoradiotherapy group than that of surgery group (91.1% vs. 62.7%, Hazard ratio 3.976, 95% Confidence interval 1.076?14.696, p=0.039). Patients who had local recurrence after definitive chemoradiotherapy received endoscopic submucosal dissection or photodynamic therapy as salvage therapies, and resulted in no disease progression and a good prognosis.
Conclusions: Definitive chemoradiotherapy may become a promising alternative therapy comparable with radical esophagectomy in patients with clinical T1bN0M0 esophageal squamous cell carcinoma. Early detection of recurrence by frequent follow-up after definitive chemoradiotherapy is important to control disease within local recurrence, and salvage therapy for local lesions could contribute to long term survival. |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0364-2313 |
| EISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1432-2323 |
| PubMed番号 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
33620541 |
| 出版社DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1007/s00268-021-06016-4 |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
WJS-45-1835.pdf (2.4 MB)
