| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2022-10-11 |
| タイトル |
|
|
タイトル |
Positive relationships between annual changes in salt intake and plasma B-type natriuretic peptide levels in the general population without hypertension and heart diseases |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
Annual change |
| キーワード |
|
|
主題 |
B-type natriuretic peptide |
| キーワード |
|
|
主題 |
General population |
| キーワード |
|
|
主題 |
Salt intake |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Ohashi, Naro
Takase, Hiroyuki
Aoki, Taro
Ishigaki, Sayaka
Iwakura, Takamasa
Isobe, Shinsuke
Fujikura, Tomoyuki
Kato, Akihiko
Yasuda, Hideo
|
| 書誌情報 |
Hypertension Research
巻 45,
号 6,
p. 944-953,
発行日 2022-06
|
| 出版者 |
|
|
出版者 |
Springer Nature |
| 出版者 |
|
|
出版者 |
日本高血圧学会 = The Japanese Society of Hypertension |
| 権利 |
|
|
権利情報 |
This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1038/s41440-022-00914-3 |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Excessive salt intake causes hypertension and heart diseases. B-type natriuretic peptide (BNP) is a surrogate marker of heart disease, and a slightly elevated BNP level is associated with a poor prognosis. Our previous cross-sectional study demonstrated that plasma BNP has a significant positive association with daily salt intake in the general population. However, the relationship between changes in salt intake and changes in plasma BNP remains unknown.
We recruited 3051 participants without hypertension or electrocardiogram abnormalities who underwent annual health check-ups for two consecutive years. Clinical parameters, including plasma BNP, were obtained, and daily salt intake was evaluated using urinary samples. Annual changes in these parameters were calculated.
The median plasma BNP level was 12.9pg/mL, and the daily salt intake was 8.73±1.89g. The annual changes in plasma BNP and daily salt intake were 4.79±36.38% and 2.01±21.80%, respectively. Participants in the highest quartile of annual changes in daily salt intake showed the largest annual changes in plasma BNP. Annual changes in plasma BNP indicated a significant positive association with daily salt intake. Moreover, multiple linear regression analyses revealed that annual changes in plasma BNP showed a significant positive association with daily salt intake after adjustments.
Our study showed a significant positive relationship between annual changes in plasma BNP and annual changes in daily salt intake. The suppression of plasma BNP is therefore induced by salt intake restriction. The monitoring of plasma BNP while reducing salt intake may therefore prevent heart diseases and lead to improved prognoses in the general population without heart diseases. |
| ISSN |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0916-9636 |
| EISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1348-4214 |
| NII書誌ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA10847079 |
| PubMed番号 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
35422510 |
| 出版社DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1038/s41440-022-00914-3 |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
Hypertens Res-45-944.pdf (1.2 MB)
