| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2022-12-07 |
| タイトル |
|
|
タイトル |
Serum S100A8 and S100A9 as prognostic biomarkers in acute exacerbation of idiopathic pulmonary fibrosis |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
S100A8 |
| キーワード |
|
|
主題 |
S100A9 |
| キーワード |
|
|
主題 |
Calgranulin |
| キーワード |
|
|
主題 |
Acute exacerbation |
| キーワード |
|
|
主題 |
Idiopathic pulmonary fibrosis |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Tanaka, Kazuki
Enomoto, Noriyuki
Hozumi, Hironao
Isayama, Takuya
Naoi, Hyogo
Aono, Yuya
Katsumata, Mineo
Yasui, Hideki
Karayama, Masato
Suzuki, Yuzo
Furuhashi, Kazuki
Fujisawa, Tomoyuki
Inui, Naoki
Nakamura, Yutaro
Suda, Takafumi
|
| 書誌情報 |
Respiratory Investigation
巻 59,
号 6,
p. 827-836,
発行日 2021-11
|
| 出版者 |
|
|
出版者 |
Elsevier |
| 出版者 |
|
|
出版者 |
日本呼吸器学会 = The Japanese Respiratory Society |
| 権利 |
|
|
権利情報 |
Copyright?2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license?https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| 権利 |
|
|
権利情報 |
"This is the accepted manuscript version. The formal published version is available at ""https://doi.org//10.1016/j.resinv.2021.05.008""." |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background: Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is a devastating and life-threatening condition during its clinical course. Biomarkers for precisely anticipating the prognosis of AE-IPF remain to be fully established. The objective of this study was to clarify whether S100A8 and S100A9, which are calcium-binding proteins mainly produced by activated neutrophils, are significant prognostic biomarkers in AE-IPF.
Methods: Thirty-seven patients with AE-IPF who were diagnosed and treated at our hospital were retrospectively evaluated. The serum levels of S100A8 and S100A9 were measured using enzyme-linked immunosorbent assay, and the relationships between these levels and clinical parameters or prognosis were evaluated.
Results: The serum levels of S100A8 (median 386.5ng/mL) and S100A9 (median 60.2ng/mL) in patients with AE-IPF were significantly higher than those in age-matched healthy controls and in patients at IPF diagnosis (p<0.001 for all combinations). The serum levels of S100A8 negatively correlated with percent forced vital capacity (r=?0.356, p=0.049) and positively correlated with peripheral white blood cell number (r=0.509, p=0.002). Immunohistochemical staining of autopsy lung specimens showed that neutrophils, present mainly in the alveolar septum, were positive for S100A8 and S100A9. Patients with AE-IPF with higher levels of S100A8 or S100A9 showed significantly worse 3-month survival than those with lower levels (log-rank test, both p=0.028). Finally, in multivariate analysis, the serum levels of both S100A8 and S100A9 were significant prognostic factors (hazard ratio 4.032, p=0.023 and hazard ratio 4.327, p=0.012).
Conclusion: The serum levels of S100A8 and S100A9 at AE were significant prognostic biomarkers in patients with AE-IPF. |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
2212-5345 |
| EISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
2212-5353 |
| NII書誌ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12579673 |
| PubMed番号 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
34154976 |
| 出版社DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1016/j.resinv.2021.05.008 |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
Respir Investig-59-827.pdf (9.3 MB)
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