| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2022-12-16 |
| タイトル |
|
|
タイトル |
Clinical significance of cold-inducible RNA-binding protein in idiopathic pulmonary fibrosis |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
Biomarker |
| キーワード |
|
|
主題 |
Cold-inducible RNA-binding protein |
| キーワード |
|
|
主題 |
Disease progression |
| キーワード |
|
|
主題 |
Idiopathic pulmonary fibrosis |
| キーワード |
|
|
主題 |
Prognosis |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| その他のタイトル |
|
|
その他のタイトル |
CIRBP in IPF |
| 著者 |
Hozumi, Hironao
Kataoka, Kensuke
Kondoh, Yasuhiro
Isayama, Takuya
Okada, Jun
Sugiura, Katsunori
Mori, Kazutaka
Kono, Masato
Suzuki, Yuzo
Karayama, Masato
Furuhashi, Kazuki
Enomoto, Noriyuki
Fujisawa, Tomoyuki
Inui, Naoki
Nakamura, Yutaro
Suda, Takafumi
|
| 書誌情報 |
Chest
巻 160,
号 6,
p. 2149-2157,
発行日 2021-12
|
| 出版者 |
|
|
出版者 |
Elsevier |
| 出版者 |
|
|
出版者 |
American College of Chest Physicians |
| 権利 |
|
|
権利情報 |
Copyright 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license?https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| 権利 |
|
|
権利情報 |
"This is the accepted manuscript version. The formal published version is available at ""https://doi.org/10.1016/j.chest.2021.06.067""." |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is associated with a poor prognosis with variable clinical course. Early identification of patients at high risk for disease progression and death would lead to early therapeutic intervention and thereby improvement of outcomes. Cold-inducible RNA-binding protein (CIRBP) is produced in response to cellular stresses, which is implicated in multiple biological processes, including cell survival and proliferation.
RESEARCH QUESTION: Is CIRBP a useful biomarker for predicting the outcomes of patients with IPF?
STUDY DESIGN AND METHODS: This study included 95 and 93 patients with IPF from two independent hospitals (derivation and validation cohorts, respectively). The association s of serum CIRBP level upon IPF diagnosis with disease progression within 1 year after diagnosis (i.e. ?10% relative decline in percent predicted forced vital capacity or death) and all-cause mortality were retrospectively analysed. Discrimination performances for predicting these outcomes were evaluated using the c-index.
RESULTS: Serum and lung tissue CIRBP levels were higher in patients with IPF than in control subjects. In the derivation cohort, the CIRBP high sub-group had significantly higher 1-year disease progression rates and lower cumulative survival rates than the CIRBP low sub-group, and the results were replicated in the validation cohort. In multivariate analyses, high serum CIRBP level was independently associated with higher 1-year disease progression and all-cause mortality rates in both cohorts. Combining the Gender-Age-Physiology and serum CIRBP models improved the c-indices for predicting 1-year disease progression and all-cause mortality compared with that of each model alone. The c-indices of serum CIRBP were particularly high in patients with Gender-Age-Physiology stage I.
INTERPRETATION: This study successfully validated that serum CIRBP level was an independent predictor of 1-year disease progression and all-cause mortality in IPF. CIRBP is a promising biomarker that can help identify high-risk patients with IPF, especially in the early stage. |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0012-3692 |
| EISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1931-3543 |
| NII書誌ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00603511 |
| PubMed番号 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
34252438 |
| 出版社DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1016/j.chest.2021.06.067 |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
Chest-160-2149.pdf (1.6 MB)
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