| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2023-01-13 |
| タイトル |
|
|
タイトル |
Long-term stability of 24 synthetic cannabinoid metabolites spiked into whole blood and urine for up to 168 days, and the comparable study for the 6 metabolites in non-spiked real case specimens stored for several years |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
Synthetic cannabinoid metabolite |
| キーワード |
|
|
主題 |
Long-term stability |
| キーワード |
|
|
主題 |
Blood and urine |
| キーワード |
|
|
主題 |
Human authentic specimens |
| キーワード |
|
|
主題 |
Deep-freezing |
| キーワード |
|
|
主題 |
LC–MS/MS |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Minakata, Kayoko
Hasegawa, Koutaro
Nozawa, Hideki
Yamagishi, Itaru
Miyoshi, Naotomo
Suzuki, Masako
Kitamoto, Takuya
Kondo, Minako
Watanabe, Kanako
Suzuki, Osamu
|
| 書誌情報 |
Forensic Toxicology
巻 40,
号 2,
p. 289-301,
発行日 2022-07
|
| 出版者 |
|
|
出版者 |
Springer Nature |
| 出版者 |
|
|
出版者 |
日本法中毒学会 = Japanese Association of Forensic Toxicology |
| 権利 |
|
|
権利情報 |
This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s11419-022-00613-1 |
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Purpose The aim of this study is to investigate the stabilities of the 24 synthetic cannabinoid metabolites (SCMs) in blood and urine at various temperatures from –30 to 37℃ stored for 1 to 168 days. In addition, experiments of stabilities at lower temperatures and for much longer duration have been performed as described below.
Methods The quantification was performed by liquid chromatography–tandem mass spectrometry (LC–MS/MS). The blank blood and urine spiked with SCMs and non-spiked real case (authentic) specimens were incubated at 37℃ up to 56 days and at 22, 4 or –30℃ up to 168 days. The non-spiked authentic blood and urine specimens were also stored at –30 or –80℃ for 1, 3 or 5 years to investigate stabilities during very long time frames.
Results All the 24 SCMs were much more stable in urine than in blood at 37, 22 or 4℃. All 24 SCMs spiked into blood or urine were stable at –30℃ for up to 168 days. The 6 SCMs in the authentic specimens exhibited long stabilities at –30 or –80℃ for 3 to 5 years. Some tendencies were observed according to the relation between the structures of SCMs and their stabilities.
Conclusions The long-term stabilities of 24 SCMs in spiked samples and those of 6 SCMs in the authentic specimens were examined using LC–MS/MS. SCMs were largely very stable and usable several years after storage at –30 or –80℃. |
| ISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1860-8965 |
| EISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1860-8973 |
| NII書誌ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12435006 |
| PubMed番号 |
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|
関連タイプ |
isVersionOf |
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|
識別子タイプ |
PMID |
|
|
関連識別子 |
36454405 |
| 出版社DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1007/s11419-022-00613-1 |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
Forensic Toxicol-40-289.pdf (2.1 MB)
