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Effect of CD4+CD25+ T Cell-Depletion on Acute Lethal Infection of Mice with Trypanosoma congolense
http://hdl.handle.net/10271/452
http://hdl.handle.net/10271/452c316bdc3-66ff-42a0-ab25-bd4e8bf65d13
名前 / ファイル | ライセンス | アクション |
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110006878921.pdf (886.8 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-08-27 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Effect of CD4+CD25+ T Cell-Depletion on Acute Lethal Infection of Mice with Trypanosoma congolense | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | CD4[+] CD25[+] T cell | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | depletion | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Th1 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Th2 cytokines | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | trypanosomosis | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | trypanotolerance | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
その他のタイトル | ||||||
その他のタイトル | Trypanosoma congolense急性感染期マウスにおけるCD4/CD25陽性T細胞の役割 (寄生虫病学) | |||||
言語 | ja | |||||
その他のタイトル | ||||||
その他のタイトル | 【Parasitology】 | |||||
言語 | en | |||||
著者 |
ナマンガラ, ボニフェス
× ナマンガラ, ボニフェス× 横山, 直明× 池原, 譲× 田口, 修× 辻村, 邦夫× 杉本, 千尋× 井上, 昇 |
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書誌情報 |
en : The Journal of Veterinary Medical Science ja : 日本獣醫學会会誌 巻 70, 号 8, p. 751-759, 発行日 2008-08-25 |
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出版者 | ||||||
言語 | ja | |||||
出版者 | 日本獣医学会 | |||||
権利 | ||||||
言語 | ja | |||||
権利情報 | (C) 日本獣医学会 | |||||
権利 | ||||||
言語 | ja | |||||
権利情報 | 本文データは学協会の許諾に基づきCiNiiから複製したものである | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Despite the immense socio-economic repercussions of African trypanosomosis (AT), there is currently no effective control measure against the disease. Characterization of mechanisms governing resistance and/or susceptibility to AT could suggest interventions that might lead to more effective disease control. The present study was designed in an attempt to address the possible role of CD4^+CD25^+ T cells during an acute lethal infection of mice with Trypanosoma congolense, the causative agent of AT in domestic animals, through selective depletion using anti-CD25 monoclonal antibody. Accordingly, CD4^+CD25^+ T-cell-depletion resulted in a significant reduction or delay in parasitemia, pathology, and mortality, as compared to controls. The apparent resistance in CD4^+CD25^+ T-cell-depleted mice correlated with a profound suppression of Th2 cytokines in vitro and in vivo, culminating in a net Th1 cytokine environment. Cumulatively, these findings suggest that CD4^+CD25^+ T-cell-depletion improves the trypanotolerance of highly susceptible BALB/c mice acutely infected with the lethal T. congolense. | |||||
言語 | en | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | アフリカトリパノソーマ症 (AT) は家畜およびヒトの健康を著しく損なう、獣医学および医学上きわめて重要な熱帯原虫病である.しかしながらATに有効なワクチンおよび安全な治療薬はない.野生動物やアフリカ在来品種のウシではATに自然抵抗性を有することが知られているが、獲得免疫によるAT抵抗性メカニズムは不明である.本研究ではTrypanosoma congolense (Tc) 急性感染期マウスにおけるCD4/CD25陽性T細胞の役割を、抗CD25モノクローナル抗体 (抗CD25) 処置によって同細胞群を選択的に排除することで解析した.その結果,抗CD25処置群では感染初期の末梢血液中におけるTc増殖が有意に抑制され、生存日数の延長が観察された.また、抗CD25処置群のサイトカイン応答ならびにTc抗原特異的抗体応答はいずれも対照群とは逆にTh1タイプに偏っていた.以上の結果はTc感染抵抗性に感染初期のTh1タイプ免疫応答活性化が必要であることを示唆している. | |||||
言語 | ja | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0916-7250 | |||||
EISSN | ||||||
収録物識別子タイプ | EISSN | |||||
収録物識別子 | 1347-7439 | |||||
NII論文ID | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | NAID | |||||
関連識別子 | 110006878921 | |||||
NII書誌ID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10796138 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 18772548 | |||||
医中誌論文ID | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | ICHUSHI | |||||
関連識別子 | 2009002592 | |||||
出版社DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1292/jvms.70.751 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |