| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-08-27 |
| タイトル |
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タイトル |
Irradiation in Adulthood as a New Model of Schizophrenia |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Iwata, Yasuhide
Suzuki, Katsuaki
Wakuda, Tomoyasu
Seki, Norihito
Thanseem, Ismail
Matsuzaki, Hideo
Mamiya, Takayoshi
Ueki, Takatoshi
Mikawa, Sumiko
Sasaki, Takeshi
Suda, Shiro
Yamamoto, Shigeyuki
Tsuchiya, Kenji J.
Sugihara, Genichi
Nakamura, Kazuhiko
Sato, Kohji
Takei, Nori
Hashimoto, Kenji
Mori, Norio
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| 書誌情報 |
en : PLoS ONE
巻 3,
号 5,
p. e2283,
発行日 2008-05-28
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| 出版者 |
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出版者 |
Public Library of Science (PLoS) |
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言語 |
en |
| 権利 |
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|
権利情報 |
Copyright 2008 Iwata et al. |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Background: Epidemiological studies suggest that radiation exposure may be a potential risk factor for schizophrenia in adult humans. Here, we investigated whether adult irradiation in rats caused behavioral abnormalities relevant to schizophrenia. Methodology/Principal Findings: A total dose of 15-Gy irradiation in six fractionations during 3 weeks was exposed to the forebrain including the subventricular zone (SVZ) and subgranular zone (SGZ) with male rats in the prone position. Behavioral, immunohistochemical, and neurochemical studies were performed three months after fractionated ionizing irradiation. Three months after fractionated ionizing irradiation, the total numbers of BrdU-positive cells in both the SVZ and SGZ zones of irradiated rats were significantly lower than those of control (sham-irradiated) rats. Hyperactivity after administration of the dopaminergic agonist methamphetamine, but not the N-methyl-D-aspartate (NMDA) receptor antagonist dizocilpine, was significantly enhanced in the irradiated rats although spontaneous locomotion in the irradiated rats was significantly lower than that of controls. Behavioral abnormalities including auditory sensory gating deficits, social interaction deficits, and working memory deficits were observed in the irradiated rats. Conclusion/Significance: The present study suggests that irradiation in adulthood caused behavioral abnormalities relevant to schizophrenia, and that reduction of adult neurogenesis by irradiation may be associated with schizophrenia-like behaviors in rats. |
| 出版社DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.1371/journal.pone.0002283 |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
PLoS ONE-3-2283.pdf (427.0 kB)
