{"_buckets": {"deposit": "ec98a01e-3a2a-4dab-a20a-eccb4e8970a8"}, "_deposit": {"created_by": 4, "id": "3736", "owners": [4], "pid": {"revision_id": 0, "type": "depid", "value": "3736"}, "status": "published"}, "_oai": {"id": "oai:hama-med.repo.nii.ac.jp:00003736", "sets": ["11"]}, "author_link": [], "item_3_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Predictors of AE in biopsy-proven IPF"}]}, "item_3_biblio_info_5": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2020-05", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3", "bibliographicPageEnd": "184", "bibliographicPageStart": "177", "bibliographicVolumeNumber": "58", "bibliographic_titles": [{"bibliographic_title": "Respiratory Investigation"}]}]}, "item_3_description_30": {"attribute_name": "フォーマット", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_3_description_9": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Background: Acute exacerbation (AE) is a major cause of death in patients with idiopathic pulmonary fibrosis (IPF). Current evidence on AE-IPF was largely based on clinical, rather than pathological, analyses.\nMethods: We investigated AE incidence and its predictors using clinical, radiological, and pathological data of patients diagnosed with IPF by multi-disciplinary discussion.\nThis study, a secondary analysis of previous research, included 155 patients with IPF who underwent surgical lung biopsy (SLB). Cumulative AE incidence was evaluated by the Kaplan?Meier method.\nPredictors of AE-IPF were analyzed with a Fine-Gray subdistribution hazard model. Sub-analysis was performed using propensity score-matching analysis.\nResults: In this cohort, median age was 66 years and median percent-predicted forced vital capacity 82.8%. The cumulative AE incidence rates at 30-days and one-year post-SLB were 1.9% and 7.6%, respectively. On multivariable analysis, a lower percent-predicted diffusing capacity of the lung for carbon monoxide (%DLCO) (hazard ratio 0.98 per 1% increase, P=0.02) and fibroblastic foci (FF)-present (vs. absent; hazard ratio 3.01, P=0.04) were independently associated with higher incidence of AE. The propensity score-matching analysis with adjustment for age, gender, and %DLCO revealed that the cumulative AE incidence rate was significantly higher in the FF-present subgroup than in the FF-absent subgroup (1-year incidence rate, 10.5% vs. 0%, respectively; P=0.04 by Gray’s test).\nConclusions: FF and %DLCO were independent predictors of AE in patients with biopsy-proven IPF. FF may be associated with the pathogenesis of AE-IPF.", "subitem_description_type": "Abstract"}]}, "item_3_publisher_6": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Elsevier"}]}, "item_3_relation_26": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "32205147", "subitem_relation_type_select": "PMID"}}]}, "item_3_relation_28": {"attribute_name": "出版社DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1016/j.resinv.2020.02.004", "subitem_relation_type_select": "DOI"}}]}, "item_3_rights_7": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "Copyright 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/"}]}, "item_3_select_2": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"subitem_select_item": "Journal Article", "subitem_select_language": "en"}]}, "item_3_source_id_19": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "2212-5345", "subitem_source_identifier_type": "ISSN"}]}, "item_3_source_id_20": {"attribute_name": "EISSN", "attribute_value_mlt": [{"subitem_source_identifier": "2212-5353", "subitem_source_identifier_type": "ISSN"}]}, "item_3_version_type_32": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Kishaba, Tomoo"}]}, {"creatorNames": [{"creatorName": "Hozumi, Hironao"}]}, {"creatorNames": [{"creatorName": "Fujisawa, Tomoyuki"}]}, {"creatorNames": [{"creatorName": "Nei, Yuichiro"}]}, {"creatorNames": [{"creatorName": "Enomoto, Noriyuki"}]}, {"creatorNames": [{"creatorName": "Sugiura, Hiroaki"}]}, {"creatorNames": [{"creatorName": "Kitani, Masashi"}]}, {"creatorNames": [{"creatorName": "Suda, Takafumi"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2021-07-01"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Respir Investig-58-177.pdf", "filesize": [{"value": "998.7 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 998700.0, "url": {"label": "Respir Investig-58-177.pdf", "url": "https://hama-med.repo.nii.ac.jp/record/3736/files/Respir Investig-58-177.pdf"}, "version_id": "92396f23-0736-49b7-9ccf-05d9ee7e60b0"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Acute exacerbation", "subitem_subject_scheme": "Other"}, {"subitem_subject": "diffusing capacity of the lung for carbon monoxide", "subitem_subject_scheme": "Other"}, {"subitem_subject": "fibroblastic foci", "subitem_subject_scheme": "Other"}, {"subitem_subject": "idiopathic pulmonary fibrosis", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Predictors of Acute Exacerbation in Biopsy-proven Idiopathic Pulmonary Fibrosis", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Predictors of Acute Exacerbation in Biopsy-proven Idiopathic Pulmonary Fibrosis", "subitem_title_language": "en"}]}, "item_type_id": "3", "owner": "4", "path": ["11"], "permalink_uri": "http://hdl.handle.net/10271/00003862", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2021-07-01"}, "publish_date": "2021-07-01", "publish_status": "0", "recid": "3736", "relation": {}, "relation_version_is_last": true, "title": ["Predictors of Acute Exacerbation in Biopsy-proven Idiopathic Pulmonary Fibrosis"], "weko_shared_id": -1}
Predictors of Acute Exacerbation in Biopsy-proven Idiopathic Pulmonary Fibrosis
http://hdl.handle.net/10271/00003862
http://hdl.handle.net/10271/00003862