| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2021-07-01 |
| タイトル |
|
|
タイトル |
Predictors of Acute Exacerbation in Biopsy-proven Idiopathic Pulmonary Fibrosis |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
Acute exacerbation |
| キーワード |
|
|
主題 |
diffusing capacity of the lung for carbon monoxide |
| キーワード |
|
|
主題 |
fibroblastic foci |
| キーワード |
|
|
主題 |
idiopathic pulmonary fibrosis |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| その他のタイトル |
|
|
その他のタイトル |
Predictors of AE in biopsy-proven IPF |
| 著者 |
Kishaba, Tomoo
Hozumi, Hironao
Fujisawa, Tomoyuki
Nei, Yuichiro
Enomoto, Noriyuki
Sugiura, Hiroaki
Kitani, Masashi
Suda, Takafumi
|
| 書誌情報 |
Respiratory Investigation
巻 58,
号 3,
p. 177-184,
発行日 2020-05
|
| 出版者 |
|
|
出版者 |
Elsevier |
| 権利 |
|
|
権利情報 |
Copyright 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background: Acute exacerbation (AE) is a major cause of death in patients with idiopathic pulmonary fibrosis (IPF). Current evidence on AE-IPF was largely based on clinical, rather than pathological, analyses.
Methods: We investigated AE incidence and its predictors using clinical, radiological, and pathological data of patients diagnosed with IPF by multi-disciplinary discussion.
This study, a secondary analysis of previous research, included 155 patients with IPF who underwent surgical lung biopsy (SLB). Cumulative AE incidence was evaluated by the Kaplan?Meier method.
Predictors of AE-IPF were analyzed with a Fine-Gray subdistribution hazard model. Sub-analysis was performed using propensity score-matching analysis.
Results: In this cohort, median age was 66 years and median percent-predicted forced vital capacity 82.8%. The cumulative AE incidence rates at 30-days and one-year post-SLB were 1.9% and 7.6%, respectively. On multivariable analysis, a lower percent-predicted diffusing capacity of the lung for carbon monoxide (%DLCO) (hazard ratio 0.98 per 1% increase, P=0.02) and fibroblastic foci (FF)-present (vs. absent; hazard ratio 3.01, P=0.04) were independently associated with higher incidence of AE. The propensity score-matching analysis with adjustment for age, gender, and %DLCO revealed that the cumulative AE incidence rate was significantly higher in the FF-present subgroup than in the FF-absent subgroup (1-year incidence rate, 10.5% vs. 0%, respectively; P=0.04 by Gray’s test).
Conclusions: FF and %DLCO were independent predictors of AE in patients with biopsy-proven IPF. FF may be associated with the pathogenesis of AE-IPF. |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
2212-5345 |
| EISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
2212-5353 |
| PubMed番号 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
32205147 |
| 出版社DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1016/j.resinv.2020.02.004 |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
Respir Investig-58-177.pdf (998.7 kB)
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