| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2023-10-02 |
| タイトル |
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|
タイトル |
Disc degeneration could be recovered after chemonucleolysis with condoliase. −1 year clinical outcome of condoliase therapy− |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
|
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Banno, Tomohiro
Hasegawa, Tomohiko
Yamato, Yu
Yoshida, Go
Arima, Hideyuki
Oe, Shin
Mihara, Yuki
Yamada, Tomohiro
Ide, Koichiro
Watanabe, Yuh
Kurosu, Kenta
Nakai, Keiichi
Matsuyama, Yukihiro
|
| 書誌情報 |
en : Journal of Orthopaedic Science
巻 27,
号 4,
p. 767-773,
発行日 2022-07
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| 出版者 |
|
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出版者 |
Elsevier |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
日本整形外科学会 |
|
言語 |
ja |
| 出版者 |
|
|
出版者 |
The Japanese Orthopaedic Association |
|
言語 |
en |
| 権利 |
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|
権利情報 |
Copyright 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| 権利 |
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|
権利情報 |
This is the accepted manuscript version. The formal published version is available at "https://doi.org/10.1016/j.jos.2021.05.005". |
| 抄録 |
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|
内容記述タイプ |
Abstract |
|
内容記述 |
Background
Condoliase-induced chemonucleolysis is a less-invasive alternative treatment for lumbar disc herniation (LDH); however, its long-term clinical outcome is still unclear. This study aimed to investigate 1-year clinical outcomes and assess radiographs after chemonucleolysis with condoliase.
Methods
We enrolled patients with LDH who received condoliase injection with a follow-up period of>1 year. Sixty patients (37 men, 23 women; mean age, 44.5 ± 18.9 years; mean follow-up period, 22.0 ± 6.0 months) were analyzed. Changes in disc height and degeneration were evaluated using magnetic resonance imaging. Visual analog scale (VAS) scores for leg and back pain and the Oswestry disability index (ODI) were obtained. All data were assessed at baseline, 1-month, 3-month, and 1-year follow-up.
Results
Surgical treatment was subsequently required in 8 patients (12.5%) after condoliase therapy. Their ODI and VAS scores for leg pain and back pain significantly improved at 1 year, as in those who received condoliase therapy only. On MRI, progression of Pfirrmann grade was observed in 23 patients (44.2%) at 3 months; however, 8 patients recovered to baseline at 1 year. The mean disc height decreased at 3 months; however, it recovered at 1 year. Disc height recovery (disc recovery rate>50%) was observed in 30.8% of the patients. Patients with disc height recovery were significantly younger than those without. Patients with longer symptom duration (≥1 year) showed significantly lower rates of effectiveness compared with those with shorter symptom durations (<1 year).
Conclusions
Chemonucleolysis with condoliase is a safe and minimally invasive treatment. Disc degeneration induced by chemonucleolysis could be recovered, particularly in younger patients. Prolonged symptom duration had adverse effects on outcome; thus, therapeutic intervention at the optimal time is needed. |
| ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0949-2658 |
| EISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
1436-2023 |
| NII書誌ID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA11052566 |
| PubMed番号 |
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関連タイプ |
isVersionOf |
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識別子タイプ |
PMID |
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関連識別子 |
34144880 |
| 出版社DOI |
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|
関連タイプ |
isVersionOf |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.1016/j.jos.2021.05.005 |
| 著者版フラグ |
|
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出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
J Orthop Sci-27-767.pdf (1.6 MB)
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